Diabetes Type 2 Meta Analysis - 1011 Words

Diabetes Type 2 meta-analysis Abstract Objective To compare treatment options of type2 diabetes. In reference to this a systematic review and meta-analysis of controlled trials, observation-based studies and published information was carried out in an attempt to investigate the difference of efficacy between pharmacologic treatment in Diabetes type 2, specifically the newer oral class known as the SGLT-2 Inhibitors. Research designs and methods A literature search was conducting using the keywords â€Å"Oral Type 2 Diabetes treatment options† in the domain of Pubmed, Embase, and Cochrane to find articles comparing treatment methods. The results of the literature search were utilized in conducting the research studies that had been published up†¦show more content†¦Overall it was collected that a number of type 2 diabetes drugs lowered A1C and CV risk at roughly the same degree, with the major differences noted in route of administration, side effects, and price, rather than efficacy. Most of the oral antidiabetics in question showed no difference on a 95% confidence interval in regard to reduction of all cause mortality, and cardiovascular mortality. Based on meta-analysis of these studies, it can be suggested that monotherapy with metformin is a good first line option, however other agents may prove to be similarly efficacious and appropriate for use in select patient populations as there was no notable di fference suggested in reducing cardiovascular outcomes between the drug classes. Introduction Type 2 diabetes is a major concern worldwide. Differing from type 1 diabetes that is usually diagnosed at a young age, diabetes type 2 is a type of diabetes that onsets during adulthood however the risk rises steadily in children as obesity increases. T2DM severely affects how the body metabolizes glucose: the major source of energy, and results with excess sugar in the bloodstream.1 This condition occurs where the body resists insulin effects and doesn’t produce enough insulin to manage glucose levels. Long-term complications from exposure of excess sugar in the blood affect major organs like the heart, nerve, kidney, eyes, skin, ears and can even lead to neurological conditions such as Alzheimer’s disease.1Show MoreRelatedThe Effects Of Sleep Deprivation On Insulin Resistance And Type 2 Diabetes792 Words   |  4 Pages The Effects of Sleep Deprivation on Insulin Resistance and Type 2 Diabetes A Meta-Analysis Dalal Mazraeh Saint James School of Medicine Preceptor: Maja Delibasic, M.D. ABSTRACT Sleep deprivation and sleep restriction leads to insulin resistance and the development of type 2 diabetes. To study whether shortened sleep and sleep deprivation affects insulin resistance and glucose intolerance, we developed a meta-analysis of 7 studies that research this topic. The studies included hadRead MoreWhat Factors Are Involved in the Increasing Prevalence of Type II Diabetes in Adolescents living in Sub-Saharan Africa?1279 Words   |  6 Pagesthe increasing prevalence of type II diabetes mellitus in the sub-Saharan region of Africa. - Identify the risk factors for having the disease early in life. OBJECTIVES - Assessment of the extent of the problem posed by type II diabetes. - Estimating the prevalence of type II diabetes among adolescents in Sub-Saharan Africa. - Identifying possible risk factors. - Making evidence based conclusions and recommendations for practice or further research. INTRODUCTION Diabetes mellitus is a deadly diseaseRead MoreOral Diabetic Addictions : Case Study724 Words   |  3 Pagesassessed for other parameter comparison. 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